LL-37, Tib

LL-37, tib neeg|Antimicrobial peptide|Science-Peptide

【Properties】 Dawb los yog tawm -dawb hmoov
【Purity】 Ntau dua lossis sib npaug li 95%
【Package】 5mg, 10mg
【Storage】 2-8 degree, Cia -20 degree, kaw cia
【Cov Lus Qhia Ntxiv] Peptide nqe, cov ntaub ntawv sib txuas, cov qauv tshuaj, qhov hnyav molecular, cov ntaub ntawv tshawb fawb tshawb fawb, thov email nug

 

LL-37, tib neeg yog ib tug paub tab active peptide tsim los ntawm proteolytic cleavage ntawm hCAP18, ib tug cathelicidin precursor ntawm tib neeg keeb kwm, muaj 37 amino acids, nrog ib tug cationic amphiphilic -helical qauv, thiab tsuas yog ib tug antimicrobial peptide ntawm tib neeg lub cev. Nws yog tib tsev neeg cathelicidin antimicrobial peptide hauv tib neeg lub cev. Nws yog tsim los ntawm neutrophils thiab epithelial hlwb (xws li cornea thiab conjunctiva), thiab yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob. Cov khoom no yog cov tshuaj sib xyaw ua ke ntawm high-purity catalog peptide rau kev tshawb fawb nkaus xwb, thiab tsim nyog rau kev tshawb fawb yooj yim thiab kev txhais lus hauv thaj chaw ntawm cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv pob txha, kho qhov txhab, mob thiab qog.

LL-37 muaj qhov dav dav-spectrum antimicrobial kev ua haujlwm.Kev tshuaj xyuas cov txheej txheem luam tawm hauv Infect Genet Evol hauv 2025 (cov ntaub ntawv npog txog Lub Peb Hlis 2025) pom tias LL-37 cuam tshuam ntau dua 38 kab mob, 16 fungal, thiab 16 hom kab mob, suav nrog Staphylococcus aureu MR (Staphylococcus) aeruginosa, Escherichia coli, thiab ntau lub hnab ntawv kab mob [Neshani li al., 2025]. Cov tshuaj tiv thaiv kab mob muaj xws li: (i) khi rau cov kab mob anionic membrane, tsim cov pores ua rau cytoplasmic to; (ii) inhibiting thiab rhuav tshem biofilm (MRSA thiab P. aeruginosa biofilms raug tshem tawm hauv 30 min ntawm qhov tsawg microgram concentrations); (iii) neutralizing LPS/LTA endotoxin; thiab (iv) inducing cov kab mob oxidative kev nyuaj siab.

LL-37, human is a key factor in the natural immunity of the human cornea.Huang et al. found that LL-37 was distributed throughout the corneal epithelium; the expression of LL-37 was significantly up-regulated in the regenerating epithelium 24-48 h after trauma (Invest Ophthalmol Vis Sci, 2006). Under physiological conditions (containing NaCl and human tear fluid), LL-37 effectively killed ocular pathogens such as Pseudomonas aeruginosa with an EC₅₀ = 10.3 ± 2.5 μg/mL. LL-37 induced the migration of human corneal epithelial cells (HCECs) through the receptor FPRL1, and promoted the migration of IL LL-37 induced human corneal epithelial cell (HCEC) migration through the receptor FPRL1, and promoted the secretion of cytokines such as IL-8 and IL-6 (2-23-fold increase), but did not promote cell proliferation; high concentrations (>10 ug / ml) yog cytotoxic. Yog li ntawd, qhov kev qhia siab ntawm LL-37 hauv pob txha regenerative epithelium muaj ob txoj haujlwm ntawm cov kab mob ncaj qha thiab kho qhov txhab.

Heterotrimeric peptides raws li LL-37 kuj tau pom tias muaj peev xwm kho tau cov kab mob pob txha.Ting li al. heterotrimerized LL-37 nrog tib neeg -defensin 2 kom tau txais HyHDP tus neeg sib tw peptide HDP56, uas tau pom qhov qis MIC tiv thaiv MRSA, Pseudomonas aeruginosa, thiab Fusarium solanacearum nyob rau hauv thaj tsam ntawm 3.1-6.3 µm / mL; 0.5 mg/mL HDP56 ua rau 93% cov kab mob txo qis thiab sib piv cov txiaj ntsig rau levofloxacin (5 mg / mL) hauv 15 tiam hauv tus qauv nas ntawm MRSA keratitis. Hauv tus qauv nas ntawm MRSA keratitis, 0.5 mg / mL HDP56 ua rau 93% txo cov kab mob, piv rau levofloxacin (5 mg / mL), thiab tsis ua rau muaj kev tiv thaiv hauv 15 tiam (BMJ Qhib Ophthalmol, 2023).

ll recruiting hlwb tiv thaiv kab mob thiab txhawb keratinocyte migration (mob inflammatory theem); nce - tswj VEGF los txhawb kev tsim cov tshuaj angiogenesis thiab txhawb nqa fibroblast migration (proliferative phase); thiab tswj collagen synthesis thiab ECM remodeling kom txo tau caws pliav (remodeling phase) [J Funct Biomater, 2025]. Hais txog kev xa khoom, PLGA nanoparticles lossis keratin hydrogels encapsulating LL-37 txhawb nqa tag nrho cov tawv nqaij qhov txhab zoo. Ib qho randomized ob-dig muag tswj kev sim (NCT04098562) luam tawm xyoo 2023 pom tias LL-37 qab zib tau zoo dua rau cov placebo raws li cov ntaub so ntswg loj hlob nyob rau hnub 7, 14, 21, thiab 28 hauv cov neeg mob me me mus rau nruab nrab tus kab mob ntshav qab zib ko taw-0.30sp, 0.006, thiab 0.037, ntsig txog) [Suwarsa et al. Arch Dermatol Res, 2023].

Immunomodulation:LL-37 muaj ob qho tib si pro- mob thiab tiv thaiv- inflammatory los ntawm chemotaxis ntawm neutrophils thiab monocytes los ntawm FPRL1, EGFR thiab lwm yam receptors, thiab kev tswj ntawm NF-κB thiab p38 MAPK signaling.

Anti- qog:LL-37 engineered derivatives (piv txwv li, 17BIPHE2) muaj kev xaiv los tiv thaiv qog noj ntshav thaum khaws cov tshuaj tua kab mob.

Antiviral:Ua kom puas lub hnab ntawv ntawm cov kab mob hauv hnab ntawv (HIV-1, RSV, thiab lwm yam) thiab inhibits tus kab mob nkag thiab rov ua dua.

Cov kab mob plawv thiab cov kab mob metabolic:koom nrog hauv atherosclerosis, thrombosis, cardiac hypertrophy, thiab rog rog -sociated adipose o kev tswj; tsis zoo cuam tshuam nrog HDL cholesterol.

Cov kab mob autoimmune thiab amyloidosis:Lub luag haujlwm hauv SLE, cuam tshuam kev puas tsuaj ntawm NETs thiab tiv thaiv -amyloidogenesis.

Cov tswv yim hloov kho ntau dua (txiav, thim rov qab analogs) thiab cov tshuab nanodelivery tuaj yeem txuas ntxiv ib nrab -lub neej thiab txo qis cytotoxicity [Int J Mol Sci, 2025].

Khaws cov hmoov lyophilized ntawm -20 degree, tsis txhob rov khov thiab thawing; yaj thiab dispense ntawm -80℃rau lub sij hawm ntev cia.

Neshani A, et al. Kev txiav txim siab LL-37: Cov qauv thiab cov tshuaj tiv thaiv kab mob tiv thaiv kab mob microbial. Kab mob Genet Evol. 2025; 136:105853.

Huang LC, et al. Multifunctional luag hauj lwm ntawm tib neeg cathelicidin (LL-37) ntawm lub qhov muag nto. Invest Ophthalmol Vis Sci. 2006;47(6):2369-2380.

Ting DSJ, et al. OP-4 Kev tsim kho tshiab ntawm tib neeg los ntawm hybrid party tiv thaiv peptides rau kis kab mob keratitis. BMJ Qhib Ophthalmol. 2023;8(Suppl 1):A2.1.

Ntau yam kev ua haujlwm lom neeg ntawm daim tawv nqaij - tau txais AMPs thaum lub qhov txhab - txheej txheem kho. J Funct Biomater. 2025;16(5):174.

Suwarsa O, et al. Kev ua tau zoo ntawm LL-37 qab zib hauv kev txhim kho kev kho mob ntshav qab zib ko taw: kev sim ntsuas ob qhov muag tsis pom kev. Arch Dermatol Res. 2023;315(9):2623-2633.

Voronko OE, thiab al. Antimicrobial peptides ntawm tsev neeg cathelicidin: Tsom ntsoov rau LL-37 thiab nws cov kev hloov kho. Int J Mol Sci. 2025;26(16):8103.