Polymyxin B Sulfate

Polymyxin B Sulfate|polymyxin b sulphate|Tshuaj tua kab mob Peptide|Endotoxin Neutralization|Kev tshawb fawb-Peptide

Polymyxin B Sulfate yog ib hom tshuaj tua kab mob cationic peptide uas muaj nyob hauv tsev neeg polymyxin. Nws yog ib qho tshuaj tua kab mob uas muaj zog thiab muaj cov tshuaj tua kab mob uas muaj tshuaj lom nrog tshuaj tiv thaiv -endotoxin kev ua.Polymyxin B Sulfate neutralizes endotoxin toxicity los ntawm kev khi nrog siab affinity rau cov kab mob sab nrauv lipopolysaccharides (LPS) thiab tuaj yeem siv los ua ib qho ntxiv rau kev tshawb fawb ntawm Gram.{3} Nws tau pom tias muaj cov kab mob tua kab mob hauv vitro thiab hauv vivo, nrog rau cov kab mob tua kab mob sai sai tiv thaiv ntau yam tshuaj -tiv taus Gram- cov kab mob tsis zoo.

Polymyxin B Sulfate, raws li ib tug cationic detergent, khi rau anionic lipopolysaccharides ntawm daim nyias nyias ntawm Gram -cov kab mob tsis zoo los ntawm electrostatic cuam tshuam, rhuav tshem cov qauv ntawm daim nyias nyias thiab ua rau cov membrane permeability, ua rau cov kab mob lysis thiab tuag. Nyob rau tib lub sijhawm, nws tuaj yeem khi rau lipid Ib feem ntawm LPS rau stoichiometrically neutralize endotoxin kev ua haujlwm, thiab ob lub tswv yim no ua rau nws muaj txiaj ntsig zoo hauv kev kho tshuaj tua kab mob thiab kev tshawb fawb endotoxin tshem tawm.

1. Synergistic antimicrobial kev tshawb fawb nrog kev sib xyaw ntawm cov tshuaj
Kev sib xyaw ua ke yog ib lub tswv yim tseem ceeb rau kev soj ntsuam nrog ntau yam tshuaj -tiv taus Gram- kab mob tsis zoo.Story et al. (2025), luam tawm nyob rau hauv Frontiers in Microbiology, qhia tau hais tias kev sib xyaw ntawm peptide-neomycin coupling nrog Polymyxin B muaj kev sib koom ua ke tseem ceeb tiv thaiv cov tshuaj ntau heev- tiv thaiv Acinetobacter baumannii, Klebsiella pneumoniae thiab Pseudomonas, ua rau aerugino resistant8. Polymyxin B pom qhov txo qis 2-8-fold hauv MIC thiab tsis muaj kev txhim kho ntawm kev tiv thaiv tsis pub dhau 14 hnub.

2. Endotoxin neutralization thiab adjunctive kho mob sepsis
Polymyxin b sulphate muaj cov ntawv thov tseem ceeb hauv kev tshawb fawb sepsis thiab endotoxemia.Mayumi li al. (1999) tau tshaj tawm hauv phau ntawv xov xwm SHOCK tias qhov koob tshuaj tsawg ntawm Polymyxin B (600 U / kg, intramuscularly) ua rau 100% ciaj sia nyob hauv CLP septic nas ntawm 3 hnub (68.8% rau pab pawg tswj), thiab kuj txo cov ntshav plasma Nws kuj tseem txo qis plasma 7 thiab L-endotox. TNF- ntau lawm. Polymyxin B-raws li hemoperfusion (Toraymyxin®) tau siv ntau dua 340,000 tus neeg mob thoob ntiaj teb, thiab PMX hemoperfusion txo 28-hnub kev tuag los ntawm 45.1% mus rau 38.7% thiab 90-hnub kev tuag los ntawm 60.8% mus rau 43.4% nyob rau hauv qhov kev sim siab III. 95.3% qhov tshwm sim ntawm cov txiaj ntsig tom qab hoc.

3. Nephrotoxicity mitigation thiab tshiab formulation kev tshawb fawb
Kev siv tshuaj kho mob ntawm Polymyxin B yog txwv los ntawm koob tshuaj -dependent nephrotoxicity.Vishwakarma et al. (2025) tau tshaj tawm hauv JAC-Antimicrobial Resistance uas ib qho kev tsim tshiab ntawm supramolecular cation, VRP-034: hauv HK-2 hlwb nrog IC₅ ₀ ntawm 147 ug/mL (90.4 ug/mL rau kev lag luam muaj PMB), txo qhov tseem ceeb ntawm biomarkers 70% raum-chip qauv, thiab txo cov cim kev raug mob rau lub raum thaum ntxov los ntawm Ntau dua lossis sib npaug li 50% hauv tus qauv tsiaj.

4. Molecular engineering kev hloov kho thiab kev siv duab
Molecular engineering hloov kho tau txais kev saib xyuas kom kov yeej cov kev txwv toxicity.Brown li al. (2020) tau ua tiav hauv kev hloov kho cov tub ntxhais ntawm Polymyxin B cyclic peptides kom tau txais cov tshuaj analogues nrog kev txhim kho hauv vitro antibacterial kev ua haujlwm .Lub 2022 Frontiers hauv Chemistry tshuaj xyuas cov txheej txheem ntawm Polymyxin B molecular engineering mus kom ze, suav nrog kev tsim qauv molecular rau kev kuaj pom kab mob thiab kev kho mob.

• Dab neeg, S., et al. Frontiers hauv Microbiology, 2025, 16, 1605813.
• Mayumi, T., et al. SHOCK, 1999, 11(2), 82-86.
• Tigris theem III soj ntsuam cov ntaub ntawv (PMX hemoperfusion).
• Vishwakarma, K., et al. JAC-Antimicrobial Resistance, 2025, 7(Supplement_4), dlaf230.110.
• Brown, P., et al. Bioorganic & Medicinal Chemistry Letters, 2020, 30(11), 127163.
• Frontiers hauv Chemistry, 2022, 9, 809584.

Polymyxin B Sulfate, polymyxin b sulphate, Endotoxin Neutralization, Multidrug-Resistant Gram-Negative Bacteria, Combination Synergy