Leuprorelin acetate yog ib qho hluavtaws gonadotropin- tso cov tshuaj hormone (GnRH) analogue uas ua lub luag haujlwm tseem ceeb hauv kev kho mob endocrine niaj hnub thiab kev kho mob qog noj ntshav. Nws inhibits kev sib deev hormone secretion los ntawm kev tswj kev ua haujlwm ntawm hypothalamus-pituitary-gonadal axis (HPG axis).
Pharmacological Mechanism
Raws li ib txwm muaj lub cev nqaij daim tawv, GnRH yog tso tawm los ntawm hypothalamus hauv pulsatile yam, txhawb lub caj pas pituitary kom tso tawm luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH), yog li tswj qhov tso tawm ntawm estrogen lossis androgen los ntawm gonads.
Leuprorelin acetate nthuav tawm "ua kom ua raws li inhibition" yam ntxwv:
Thaum pib stimulation theem: Nyob rau hauv thawj theem ntawm kev siv, nws ib ntus tsub kom LH thiab FSH secretion, ua rau kom nce qib ntawm kev sib deev hormone (hu ua "flare effect").
Kev siv tsis tu ncua: Vim qhov kev txhawb nqa tas mus li ntawm GnRH receptors, cov receptors tau dhau los ua qhov tsis txaus ntseeg thiab txo qis, thaum kawg inhibiting LH thiab FSH secretion.
Cov nyhuv kawg: txo qis cov tshuaj estrogen lossis testosterone ntau hauv lub cev, ua tiav cov nyhuv "chemical castration".
