Smegglutide yog ib tug ntev - ua glucagon-zoo li peptide-1 receptor agonist (GLP-1RA) nrog 94% amino acid sequence homology rau natural human glucagon-zoo li peptide-1. Raws li qhov thib rau kev lag luam GLP-1RA thiab qhov thib peb ib zaug ib lub lim tiam ua yeeb yam ntev, nws yog siv rau kev tswj glycemic rau cov neeg laus uas muaj ntshav qab zib hom 2.
Cov tshuaj no tau pom zoo rau kev lag luam hauv Tebchaws Meskas thaum Lub Kaum Ob Hlis 2017 thiab tom qab siv ntau dua 50 lub tebchaws thiab cheeb tsam. Nws tau pom zoo hauv Suav teb thaum Lub Plaub Hlis 2021. Nws txhawb nqa cov tshuaj insulin secretion thiab inhibits glucagon tso tawm los ntawm kev ua kom lub GLP-1 receptor, nrog ib nrab ntawm - lub neej txuas mus rau 7 hnub. Thaum Lub Rau Hli 2024, qhov hnyav- poob version (lub npe lag luam: Novogene) tau pom zoo nyob hauv Suav teb loj rau lub sijhawm ntev - tswj qhov hnyav thiab tau tshaj tawm thaum lub Kaum Ib Hlis ntawm tib lub xyoo. Thaum Lub Ib Hlis Ntuj xyoo 2024, cov ntsiav tshuaj ntawm qhov ncauj smegglutide tau pom zoo hauv Suav teb, dhau los ua thawj qhov ncauj GLP-1RA tshuaj hauv lub tebchaws. Thaum Lub Peb Hlis 2024, US FDA tau pom zoo nws qhov hnyav-poob version los txo qhov kev pheej hmoo ntawm cov kab mob plawv hauv cov neeg mob hnyav uas muaj kab mob plawv. Thaum Lub Xya Hli 2025, ib qho kev qhia tshiab tau pom zoo hauv Suav teb rau semaglutide, uas tuaj yeem txo qhov kev pheej hmoo ntawm lub raum tsis ua haujlwm thiab tuag rau cov neeg mob ntshav qab zib hom 2 thiab mob raum. Cov kev mob tshwm sim hauv plab hnyuv thiab cov thyroid-txog contraindications yuav tshwm sim thaum siv. Raws li xyoo 2025, kev txhaj tshuaj semaglutide thiab cov ntsiav tshuaj yog tsim los ntawm Novo Nordisk; qhov poob phaus version tsis tau them los ntawm kev tuav pov hwm kho mob thiab yuav tsum tau sau ntawv. Thaum Lub Kaum Ob Hlis 23, nws tau tshaj tawm tias Asmeskas cov koom haum tswj hwm tau pom zoo thawj GLP-1 ntsiav tshuaj qhov ncauj qhov hnyav. Raws li lub Plaub Hlis 25, 2026, patent rau cov ntsiab lus tseem ceeb ntawm semaglutide tau tas sij hawm ntau tshaj li ib hlis dhau los, thiab tsis muaj semaglutide hauv tsev tau txais kev pom zoo hauv Suav teb.
