Atosiban, tseem hu ua Atosibanum los yog Tractocile [1], yog ib qho tshuaj tiv thaiv uterine contraction siv los ncua kev ua haujlwm ua ntej yug menyuam hauv cov poj niam cev xeeb tub hnub nyoog 24-33 lub lis piam nrog lub plawv dhia hauv plab thiab thaum muaj hnub nyoog 18 xyoo lossis laus dua. Nws yog qhia rau kev ua kom lub tsev menyuam tsis tu ncua tshwm sim ntau dua 4 zaug txhua 30 feeb (txhua qhov ntev li 30 vib nas this), nrog rau lub ncauj tsev menyuam dilation ntawm 1-3 cm (0-3 cm rau cov poj niam primiparous) thiab cervical effusion ntawm ntau tshaj 50%.
Cov kev sim tshuaj ntsuam xyuas tau pom tias atosiban muaj qhov ua tau zoo dua hauv kev tswj kev xeeb tub thiab kev yug menyuam hauv cov neeg laus uas muaj kev hem thawj ua haujlwm ua ntej tshaj li pawg tswj hwm ritodrine hydrochloride, nrog rau qhov tshwm sim qis dua ntawm qhov tsis zoo. Lub thoob ntiaj teb multicenter randomized ob - qhov muag tsis pom kev sim (APOSTEL 8) tau pom tias tom qab siv rau cov neeg mob ntawm 30–33+6 lub lis piam ntawm cev xeeb tub, tsis muaj qhov sib txawv tseem ceeb hauv perinatal mortality thiab qhov tshwm sim ntawm cov kab mob loj heev neonatal (8%) piv rau cov placebo pawg (9%).
